Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment

Brain Sciences

GilbertoA. Jiménez-Castillo¹  AlbertoJosé Mimenza-Alvarado¹  JoséAlberto Ávila-Funes¹  Teresa Juárez-Cedillo²  GustavoC. Román²  Isaac Corona-Sevilla²  SaraG. Aguilar-Navarro² 

[1] Neurology Fellowship, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico;;Geriatrics &

关键词: cerebral vascular reactivity;    frailty;    mild vascular cognitive impairment;    neuropsychological tests;    older adults;    diabetes;    transcranial doppler ultrasound;   

DOI  :  10.3390/brainsci9090214

来源: DOAJ

【 摘 要 】

Background: Frailty, a state of increased vulnerability, could play a role in the progression of vascular dementia. We aim to describe the changes in cerebrovascular reactivity of older adults with frailty and vascular-type mild cognitive impairment (MCIv). Methods: This was a cross-sectional study. A comprehensive geriatric assessment, neuropsychological evaluation, and transcranial Doppler ultrasound (TCD) was performed on 180 participants who were allocated into four groups: healthy (n = 74), frail (n = 40), MCIv (n = 35), and mixed (frail + MCIv) (n = 31). ANOVA and Kruskal−Wallis tests were used for the analysis of continuous variables with and without normal distribution. Multinomial logistic regression was constructed to identify associated covariates. Results: Subjects in the mixed group, compared to healthy group, were older (75.0 ± 5.9 vs 70.3 ± 5.9 years; p < 0.001), showed lower education (9.3 ± 6.4 vs 12.2 ± 4.0 years; p = 0.054), greater frequency of diabetes (42% vs 12%; p = 0.005), worse cognitive performance (z = −0.81 ± 0.94), and reduced left medial-cerebral artery cerebrovascular reactivity (0.43 ± 0.42 cm/s). The mixed group was associated with age (odds ratio (OR) 1.16, 95% Confidence Interval (CI) = 1.06−1.27; p < 0.001), diabetes (OR 6.28, 1.81−21.84; p = 0.004), and Geriatric Depression Scale (GDS) score (OR 1.34, 95% CI = 1.09−1.67; p = 0.007). Conclusions: Frailty among older adults was associated with worse cognitive performance, diabetes, and decreased cerebral blood flow.

【 授权许可】

Unknown