Zingiber officinale supplementation suppresses eimeriosis and regulates goblet cell response

Saudi Journal of Biological Sciences

Abdulsalam Alkhudhayri¹  Murad A. Mubaraki²  Saleh Al-Quraishy²  Felwa A. Thagfan³  Esam M. Al-Shaebi⁴  Rewaida Abdel-Gaber⁵  Mohamed A. Dkhil⁵  Saleh N. Maodaa⁵  Taghreed A. Hafiz⁵ 

[1] Corresponding author.;Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud University, Saudi Arabia;Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P. O. Box 84428, Riyadh 11671, Saudi Arabia;Department of Biology, College of Science, University of Hafr Albatin, Saudi Arabia;Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia;

关键词: Coccidia;    Zingiber officinale;    Mice;    Goblet cell;    Behavior;   

DOI  :  

来源: DOAJ

【 摘 要 】

Coccidiosis affects both domestic and wild animals and negatively impacting industries worldwide. Medicinal plants are widely used against parasites. Using infected mice with Eimeria papillata, we assessed the anticoccidial impact of Zingiber officinale extract (ZE). The animals in the first group were just given distilled water, while the animals in the second group were given ZE. The parasite's oocysts were infected into the third and fourth groups. The fourth group was given ZE for five days. The oocysts in mice faeces were reduced after treatment with ZE. The total parasitic stages were reduced after treatments by about 50%. Also, gamonts, meronts and oocysts inside the jejunum were decreased after treatment with ZE.The infection caused hypoplasia of goblet cells of jejunum. ZE was able to ameliorate the goblet cells decrease. Behavioral response of animals to infection and treatment was investigated. All of these improvements could be attributed to the existence of active chemical classes of substances identified using infrared spectroscopy. Additional experiments are required to identify the phytochemical compounds in ZE and to understand their fighting mechanism against the parasite.

【 授权许可】

Unknown