Antiseptic Polymer–Surfactant Complexes with Long-Lasting Activity against SARS-CoV-2

Polymers

Irina T. Fedyakina¹  Ali S. Turgiev¹  Eduard V. Karamov¹  Galina V. Kornilaeva¹  Viktor F. Larichev¹  Alexei R. Khokhlov²  Vyacheslav S. Molchanov²  Andrey V. Shibaev²  Olga E. Philippova² 

[1] Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia;Physics Department, Lomonosov Moscow State University, 119991 Moscow, Russia;

关键词: polyelectrolyte;    hydrogel;    surfactant;    COVID-19;    SARS-CoV-2;    disinfectant;   

DOI  :  10.3390/polym14122444

来源: DOAJ

【 摘 要 】

Antiseptic polymer gel–surfactant complexes were prepared by incorporating the low-molecular-weight cationic disinfectant cetylpyridinium chloride into the oppositely charged, slightly cross-linked polymer matrices. Three types of polymers were used: copolymers of acrylamide and sodium 2-acrylamido-2-methylpropane sulfonate; copolymers of acrylamide and sodium methacrylate; copolymers of vinylpyrrolidone and sodium methacrylate. It was shown that the rate of the release of the cationic disinfectant from the oppositely charged polymer gels could be tuned in a fairly broad range by varying the concentration of the disinfectant, the degree of swelling, and degree of cross-linking of the gel and the content/type of anionic repeat units in the polymer matrix. Polymer–surfactant complexes were demonstrated to reduce SARS-CoV-2 titer by seven orders of magnitude in as little as 5 s. The complexes retained strong virucidal activity against SARS-CoV-2 for at least one week.

【 授权许可】

Unknown