Effects of Acute Exposure to Heat Stress on Immunological and Lipid Parameters in Rats

Archives of Occupational Health

Mohammad Reza zare¹  Abdolrasoul Rahmani²  Torab Koochaki³  Fazel Rajabi⁴  saeed Yousefinejad⁴  zahra Zamanian⁴  Mohammad Ali Tajbakhsh⁵  Mohammad Reza Zarei⁶  Zahra Hashemi⁷  Aboutaleb Modaresi⁸  Marjan Gharavi⁹ 

[1] Department of Environmental Health Engineering, School of Health, Larestan University of Medical Sciences, Larestan, Iran;Department of Occupational Health Engineering, School of Health, Larestan University of Medical Sciences, Larestan, Iran;Department of Occupational Health Engineering, School of Health, Mazandaran University of Medical Sciences, Mazandaran, Iran;Department of Occupational Health Engineering, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran;Department of Occupational Health Engineering, School of Health, Tehran University of Medical Sciences, Tehran, Iran;Department of Safety Engineering, School of Safety, Esfahan University of Applied Science and Technology, Iran;Department of public Health, School of Health, Larestan University of Medical Sciences, Larestan, Iran;Modaresi Laboratory, Larestan, Fars, Iran;Occupational medicine specialist and occupational disease;

关键词: wbgt;    sprague–dawley rats;    heat stress;    immunological parameter;    lipid parameter;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Exposure to heat stress can result in lipid parameters alterations as well as immunological responses. This study was aimed to investigate these alterations and responses at different humidity and temperatures levels under controlled laboratory conditions in adult male Sprague–Dawley rats. Methods: A total 15 adult male Sprague–Dawley rats, weighing between 200 and 250 g, 10-11 weeks of age, were used in the evaluation. After one week, animals were randomly divided into three equal groups of 5 animals each. Reference group (group1) was housed in the cage under WBGT of 20(1) according to experimental design. Also, animals were subjected to mild (WBGT of 29 ( 1)) and hotter (WBGT of 33(1)) conditions (8 hr/day for one day) in the exposure chamber as group2 and group3, respectively. At the end of exposure to heat stress, blood samples were collected from the heart of rats and different parameters were determined. Results: Based on results, acute heat exposure significantly caused a decrease in serum IgG, IgM, IgA of rats in the case group compared to control group (P<0.05). Conversely, acute heat exposure resulted in a significant increase in the levels of IgE (P<0.05). There was no statistical difference for the lipid parameters after exposure to acute heat stress compared with the control group (P > 0.05). Conclusion: Acute heat stress may affect immune responses depending on the intensity of the exposure. Higher environmental temperatures (WBGT≥32°C) cause more severe changes in plasma immunoglobulins.

【 授权许可】

Unknown