Malignant tumours of the minor salivary glands: a survival analysis of 17 years from a tertiary referral cancer centre.

Journal of Postgraduate Medicine

关键词: Adolescent;    Adult;    Aged;    Carcinoma;    diagnosis;    pathology;    therapy;    Disease-Free Survival;    Female;    Human;    Male;    Middle Age;    Neoplasm Staging;    Palate;    pathology;    Retrospective Studies;    Salivary Gland Neoplasms;    diagnosis;    pathology;    therapy;    Survival Analysis;    Treatment Outcome;   

DOI  :  

来源: DOAJ

【 摘 要 】

BACKGROUND: Malignant tumours of the minor salivary glands are rare and constitute less than 0.5% of all malignant neoplasms. AIM: This study was carried out to evaluate the clinical presentation, site distribution, treatment, survival and predictors of survival in malignant minor salivary gland tumours. SETTING: A tertiary care, superspeciality referral hospital. DESIGN: Retrospective analysis. PATIENTS AND METHOD: Forty-two cases of minor salivary gland tumours treated over a period of 17 years were reviewed for clinical presentation, histopathology, stage distribution, treatment and treatment outcome. STATISTICAL ANALYSIS: Survival by Kaplan Meier Method and the outcomes were compared using log-rank test. RESULTS: The mean age of the patients was 46.9 years with a male to female ratio of 1.4:1. Majority of the patients presented with a painless progressive swelling, with 13 (31%) of them in T2 stage. About one-third of the patients had palpable lymph nodes at presentation, while none had distant metastasis. Palate was the commonest site and mucoepidermoid carcinoma was the commonest hispathological type. About 1/3 of the patients were treated with primary surgery and were followed up by adjuvant radiotherapy. Seven patients underwent palliative treatment alone. Over a mean follow-up of 30 months, 5 patients failed. The disease free survival was 72% at 5-year, none of the factors studied were found to significantly influence survival. CONCLUSIONS: Results of the present study suggest that minor salivary gland tumours should be treated with primary surgery irrespective of site and histological type to achieve best loco-regional control and survival.

【 授权许可】

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