GROWTH FACTOR AND ADIPOKINE RECEPTORS IN PATHOGENESIS AND PROGNOSIS OF ENDOMETRIAL CANCER IN PATIENTS WITH METABOLIC SYNDROME

Sibirskij Onkologičeskij Žurnal

L. А. Kolomiets¹  I. V. Kondakova²  Е. V. Shanshashvili²  N. V. Yunusova²  А. L. Chernyshova² 

[1] Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, TomskSiberian State Medical University, Tomsk;Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk;

关键词: growth factor receptors;    adipokine receptors;    cyclooxygenase-2;    endometrial cancer;    metabolic syndrome;   

DOI  :  

来源: DOAJ

【 摘 要 】

The role of growth factor receptors (insulin-like growth factor and transforming growth factor-beta) and adipokine receptors (leptin and adiponectin) in pathogenesis of endometrial cancer under conditions of metabolic syndrome is discussed. Cyclooxygenase-2 is an effector of signaling pathways activated by growth factors and cytokines. The detailed study of the mechanisms involving these proteins in pathogenesis of endometrial cancer in patients with metabolic syndrome and search for new biological prognostic markers appear to be promising.

【 授权许可】

Unknown