Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis

Nature Communications

Xiang Zhu¹  Qinong Ye¹  Xiaojie Xu¹  Juan Liu¹  Lei Kang²  Xu Gao³  Stuart B. Goodman⁴  William J. Maloney⁴  Zheng Wang⁵  Wenchao Li⁵  Zhifeng Yan⁵  Quanbo Ji⁵  Yan Wang⁵  Yameng Xu⁶  Jingbo Xiao⁷  Yuxuan Zheng⁸ 

[1]Department of Medical Molecular Biology, Beijing Institute of Biotechnology

[2]Department of Nuclear Medicine, Peking University First Hospital

[3]Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine

[4]Department of Orthopaedic Surgery, Stanford University

[5]Department of Orthopaedics, General Hospital of Chinese People’s Liberation Army

[6]Department of Traditional Chinese Medicine, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

[7]National Library of China

[8]Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Life Sciences, Peking University

DOI  :  10.1038/s41467-018-08277-5

来源: DOAJ

【 摘 要 】

Osteoarthritis (OA) is associated with cartilage degeneration, and no effective therapy exists. Here, the authors show that the HPIP protein modulates OA progression by regulating Wnt signaling, and that its knockdown in joints via AAV-mediated gene silencing attentuates pathology.

【 授权许可】

Unknown