Effects of Ionizing and Non-Ionizing Radiation on Oxidative Stress and the Total Antioxidant Status in Humans Working in Radiation Environments

Bezmiâlem Science

Ataman GÖNEL¹  İsmail KOYUNCU²  Ali Ziya KARAKILÇIK³  Hakim ÇELİK³  Davud MUSA⁴ 

[1] Clinic of Medical Biochemistry, Akçakale State Hospital, Şanlıurfa, Turkey;Department of Medical Biochemistry, Harran University School of Medicine, Şanlıurfa, Turkey;Department of Physiology, Harran University School of Medicine, Şanlıurfa, Turkey;Division of Biology, School of Social Sciences and Humanities, Şanlıurfa, Turkey;

关键词: Ionizing radiation;    non-ionizing radiation;    total oxidant status;    malondialdehyde;    protein carbonyl;    total antioxidant status;    oxidative stress index;   

DOI  :  10.14235/bs.2016.872

来源: DOAJ

【 摘 要 】

Objective:This study was conducted to investigate the effects of ionizing radiation (IR) and non-ionizing radiation (NIR) on oxidative stress and the total antioxidant status (TAS) in men working in radiation environments.Methods:The serum values of total oxidant status (TOS), malondialdehyde (MDA), and protein carbonyl (PC) in men exposed to radiation and a control group were determined. In addition, the values of the total antioxidant status (TAS) were measured in serum, and the oxidative stress index (OSI) was calculated to determine the oxidative stress. Data were analyzed by SPSS 20.0 (Chicago, IL, USA).Results:While the serum values of PC, MDA, TOS, and OSI were significantly higher in the IR group than in the control group, those of TAS were significantly lower (p<0.001, p=0.003, p<0.001, p<0.001, and p= 0.002, respectively). The serum values of PC, TOS, and OSI were significantly higher in the NIR group than in the control group (p<0.001, p=0.021, and p=0.010, respectively). In contrast, there were no significant differences in the values of TAS and MDA (p>0.05 and p>0.05, respectively) in the same groups.Conclusion:Based on these results, we determined that it had been damaged the balance between oxidants and antioxidant status in the IR and NIR groups. This effect of oxidative stress may cause a lot of damage to cellular macromolecules including lipids, proteins, and DNA.

【 授权许可】

Unknown