Green supported Cu nanoparticles on modified Fe3O4 nanoparticles using thymbra spicata flower extract: Investigation of its antioxidant and the anti-human lung cancer properties

Arabian Journal of Chemistry

Xiaoli Tang¹  Zhaodong Sun¹  Xuelian Li² 

[1] Department of Laboratory Medicine, The First People’s Hospital of Lianyungang City, Lianyungang City, Jiangsu Province 222002, People’s Republic of China;Department of Laboratory Medicine, The Fourth People’s Hospital of Lianyungang City, Lianyungang City, Jiangsu Province 222002, People’s Republic of China;

关键词: Magnetic composite;    Fe3O4/Thyme-Cu;    Antioxidant;    Human lung cancer;   

DOI  :  

来源: DOAJ

【 摘 要 】

In recent days, the green synthesized nanomagnetic biocomposites have been evolved with tremendous potential as the future biological agents. This has encouraged us to design and synthesis of a novel Cu NPs supported Thyme flower extract modified magnetic nanomaterial (Fe3O4/Thyme-Cu). It was meticulously characterized using advanced analytical techniques like FT-IR, FESEM, TEM, EDX, VSM, XRD and ICP-OES. After the characterization, the synthesized Fe3O4/Thyme-Cu nanocomposite was engaged in biological assays like study of anti-oxidant properties by DPPH mediated free radical scavenging test using BHT as a reference molecule. Thereafter, on having a significant IC50 value in radical scavenging assay, we extended the bio-application of the desired nanocomposite in anticancer study of A549, Calu6 and H358 human lung cell lines in-vitro through MTT assay. They had very low cell viability and high anti-human lung cancer activities dose-dependently against A549, Calu6 and H358 cell lines without any cytotoxicity on the normal cell line (MRC-5). The IC50 of Fe3O4/Thyme-Cu nanocomposite was 124, 265, and 181 µg/mL against A549, Calu6 and H358 cell lines, respectively. Maybe significant anti-human lung cancer potentials of Fe3O4/Thyme-Cu nanocomposite against common lung cancer cell lines are related to their antioxidant activities. So, these results suggest that synthesized Fe3O4/Thyme-Cu nanocomposite as a chemotherapeutic nanomaterial have a suitable anticancer activity against lung cell lines.

【 授权许可】

Unknown