Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare

Biomolecular Concepts

Kolkova Zuzana¹  Samec Marek¹  Holubekova Veronika¹  Kasubova Ivana¹  Kudela Erik²  Rokos Tomas²  Mazurakova Alena²  Koklesova Lenka²  Kozubik Erik²  Biringer Kamil²  Kubatka Peter³ 

[1] Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, SK-03601, Slovakia;Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, SK-03601, Slovakia;Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, SK-03601, Slovakia;

关键词: cervical cancer;    microbiome;    epigenome;    inflammation;    human papillomavirus;    3p-medicine;   

DOI  :  10.1515/bmc-2022-0005

来源: DOAJ

【 摘 要 】

One pillar of the predictive, preventive, and personalized medicine framework strategies is the female health. The evaluation of women’s lifestyle and dietary habits in context with genetic and modifiable risk factors may reflect the prevention of cervical cancer before the occurrence of clinical symptoms and prediction of cervical lesion behavior. The main aim of this review is to analyze publications in the field of precision medicine that allow the use of research knowledge of cervical microbiome, epigenetic modifications, and inflammation in potential application in clinical practice. Personalized approach in evaluating patient’s risk of future development of cervical abnormality should consider the biomarkers of the local microenvironment characterized by the microbial composition, epigenetic pattern of cervical epithelium, and presence of chronic inflammation. Novel sequencing techniques enable a more detailed characterization of actual state in cervical epithelium. Better understanding of all changes in multiomics level enables a better assessment of disease prognosis and selects the eligible targeted therapy in personalized medicine. Restoring of healthy vaginal microflora and reversing the outbreak of cervical abnormality can be also achieved by dietary habits as well as uptake of prebiotics, probiotics, synbiotics, microbial transplantation, and others.

【 授权许可】

Unknown