The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis

Microorganisms

Andreas Tauch¹  Marisol Salgado-Albarrán²  Mariana Teixeira Dornelles Parise²  Doglas Parise²  Jan Baumbach²  Vasco Ariston de Carvalho Azevedo³  Rodrigo Bentes Kato³  Anne Cybelle Pinto Gomide³  Flávia Figueira Aburjaile⁴ 

[1] Center for Biotechnology (CeBiTec), Bielefeld University, 33615 Bielefeld, Germany;Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, 85354 Freising-Weihenstephan, Germany;Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil;Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Rio de Janeiro 21040-360, Brazil;

关键词: Corynebacterium pseudotuberculosis;    transcriptional regulatory mechanisms;    transcription factors;    two-component systems;    sigma factors;    virulence;   

DOI  :  10.3390/microorganisms9020415

来源: DOAJ

【 摘 要 】

Corynebacterium pseudotuberculosis is a Gram-positive, facultative intracellular, pathogenic bacterium that infects several different hosts, yielding serious economic losses in livestock farming. It causes several diseases including oedematous skin disease (OSD) in buffaloes, ulcerative lymphangitis (UL) in horses, and caseous lymphadenitis (CLA) in sheep, goats and humans. Despite its economic and medical-veterinary importance, our understanding concerning this organism’s transcriptional regulatory mechanisms is still limited. Here, we review the state of the art knowledge on transcriptional regulatory mechanisms of this pathogenic species, covering regulatory interactions mediated by two-component systems, transcription factors and sigma factors. Key transcriptional regulatory players involved in virulence and pathogenicity of C. pseudotuberculosis, such as the PhoPR system and DtxR, are in the focus of this review, as these regulators are promising targets for future vaccine design and drug development. We conclude that more experimental studies are needed to further understand the regulatory repertoire of this important zoonotic pathogen, and that regulators are promising targets for future vaccine design and drug development.

【 授权许可】

Unknown