Association Between Serum Lactate and Unsatisfactory Outcomes in Critically Ill Children in the Immediate Post-operative Period of Liver Transplantation

Frontiers in Pediatrics

Nicolás Molano¹  Jairo Rivera²  Claudia Salinas²  Jaime Fernández-Sarmiento³  Ricardo Hernandez-Sarmiento³  Hernando Mulett³  Lorena Acevedo³  María Angélica Wilches-Cuadros⁴  Julián Augusto Palomar Dominguez⁵  Karen Moreno-Medina⁶ 

[1] Clinical Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia;Department of Liver Transplantation, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia;Department of Pediatrics and Intensive Care, Fundación Cardioinfantil-Instituto de Cardiología, Universidad de La Sabana, Bogotá, Colombia;Department of Pediatrics and Intensive Care, Fundación Cardioinfantil-Instituto de Cardiología, Universidad el Rosario, Bogotá, Colombia;Department of Pediatrics, Universidad de La Sabana, Bogotá, Colombia;Research Department, Fundación CardioInfantil-Instituto de Cardiología, Bogotá, Colombia;

关键词: biliary atresia;    child;    hypoxia;    liver failure;    mortality;    tissue donor;   

DOI  :  10.3389/fped.2021.796504

来源: DOAJ

【 摘 要 】

ObjectivesSerum lactate is a useful biomarker of tissue perfusion in critically ill patients. We evaluated the behavior of serum lactate in children in the pediatric intensive care unit (PICU) immediately after liver transplantation and its association with surgical complications, graft dysfunction and 90-day mortality.Materials and MethodsA prospective observational study carried out between November 2009 and December 2019. Multidisciplinary PICU at the University Children's Hospital, Fundación Cardioinfantil-IC, Bogotá, Colombia.Measurements and Main ResultsPatients between 1 month and 18 years of age who were in the immediate post-operative period following living-donor or cadaveric liver transplantation were included. A total of 145 patients with a median age of 14 months (IQR 8–60) met the inclusion criteria. Biliary atresia was the main diagnosis in 56.5% of the cases. A serum lactate level > 3.0 mmol/L on admission to the PICU was associated with biliary complications (AUC 0.73 95% CI 0.54–0.93; p = 0.05) and mortality (AUC 0.72 95% CI 0.63–0.8; p = 0.01). A lactate level > 2 mmol/L after 6 h in the PICU was associated with mortality (AUC 0.70 95% CI 0.54–0.83; p = 0.02). Higher lactate levels and lack of clearance were associated with the presence of tardus et parvus waveforms (p = 0.001) on liver Doppler, primary dysfunction (p < 0.001), arterial thrombosis (p < 0.001) and neurological complications (p = 0.04). There was an inverse correlation between admission lactate and the volume of fluids administered during surgery (rho = 0.36; p < 0.001). A total procedure time > 350 min, along with a vasopressor score > 7 and elevated lactate, were associated with worse outcomes (p < 0.001).ConclusionsIn post-operative pediatric liver transplant patients, the level of serum lactate is associated with post-operative surgical complications and mortality.

【 授权许可】

Unknown