Induction of Myocardial Infarction in Experimental Animals: A Review

Journal of Clinical and Diagnostic Research

Zakiah Jubri¹  Syarifah Aisyah Syed Abd Halim²  Norzana Abd Ghafar³  Srijit Das³ 

[1] Associate Professor, Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.;Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.;Professor, Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.;

关键词: coronary artery;    isoprenaline;    ligation;    myocardial infarction;   

DOI  :  10.7860/JCDR/2018/36997.12221

来源: DOAJ

【 摘 要 】

Myocardial Infarction (MI) is a major health problem worldwide. Animal models have been used extensively in scientific research. This was intended to help researchers to understand the underlying pathophysiology of MI, compensatory mechanisms involved and efficacy of treatment. Although, it is difficult to create necrosis similar to those found in human heart, various large and small animals were used to create experimental model of MI. Each of these animals and method of selection offers various advantages and disadvantages in relation to clinical studies. In the present review, we aim to highlight the different methods used to induce MI in experimental animals. These methods may be beneficial for academicians and researchers concerned with the treatment of MI.

【 授权许可】

Unknown