After-effects of 10 Hz tACS over the prefrontal cortex on phonological word decisions

Brain Stimulation

Leon Sierau¹  Michael Werchowski²  Tristan Stenner³  Gesa Hartwigsen⁴  Ekaterina Lyzhko⁴  Vera Moliadze⁴  Michael Siniatchkin⁴ 

[1] Corresponding author.;Institute of Mathematical Problems of Biology RAS - the Branch of Keldysh Institute of Applied Mathematics of Russian Academy of Sciences, Pushchino, Moscow Region, Russia;Department of Neuropediatrics, University Medical Center Schleswig Holstein, Kiel University, Germany;Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Germany;

关键词: Alpha;    Prefrontal cortex;    Plasticity;    Language;    Non-invasive brain stimulation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: Previous work in the language domain has shown that 10 Hz rTMS of the left or right posterior inferior frontal gyrus (pIFG) in the prefrontal cortex impaired phonological decision-making, arguing for a causal contribution of the bilateral pIFG to phonological processing. However, the neurophysiological correlates of these effects are unclear. The present study addressed the question whether neural activity in the prefrontal cortex could be modulated by 10 Hz tACS and how this would affect phonological decisions. Methods: In three sessions, 24 healthy participants received tACS at 10 Hz or 16.18 Hz (control frequency) or sham stimulation over the bilateral prefrontal cortex before task processing. Resting state EEG was recorded before and after tACS. We also recorded EEG during task processing. Results: Relative to sham stimulation, 10 Hz tACS significantly facilitated phonological response speed. This effect was task-specific as tACS did not affect a simple control task. Moreover, 10 Hz tACS significantly increased theta power during phonological decisions. The individual increase in theta power was positively correlated with the behavioral facilitation after 10 Hz tACS. Conclusion: Our results show a facilitation of phonological decisions after 10 Hz tACS over the bilateral prefrontal cortex. This might indicate that 10 Hz tACS increased task-related activity in the stimulated area to a level that was optimal for phonological performance. The significant correlation with the individual increase in theta power suggests that the behavioral facilitation might be related to increased theta power during language processing.

【 授权许可】

Unknown