Age-Related Pathways in Cardiac Regeneration: A Role for lncRNAs?

Frontiers in Physiology

Bruno Bernardes de Jesus¹  Magda Correia¹  Francisco Santos¹  Sandrina Nóbrega-Pereira² 

[1] Department of Medical Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal;Faculdade de Medicina, Instituto de Medicina Molecular João Lobo Antunes, Universidade de Lisboa, Lisboa, Portugal;

关键词: lncRNAs;    heart;    regeneration;    reprogramming;    transdifferentiation;   

DOI  :  10.3389/fphys.2020.583191

来源: DOAJ

【 摘 要 】

Aging imposes a barrier for tissue regeneration. In the heart, aging leads to a severe rearrangement of the cardiac structure and function and to a subsequent increased risk of heart failure. An intricate network of distinct pathways contributes to age-related alterations during healthy heart aging and account for a higher susceptibility of heart disease. Our understanding of the systemic aging process has already led to the design of anti-aging strategies or to the adoption of protective interventions. Nevertheless, our understanding of the molecular determinants operating during cardiac aging or repair remains limited. Here, we will summarize the molecular and physiological alterations that occur during aging of the heart, highlighting the potential role for long non-coding RNAs (lncRNAs) as novel and valuable targets in cardiac regeneration/repair.

【 授权许可】

Unknown