Predictive Value of Urinary Neutrophil Gelatinase-associated Lipocalin and Serum Ischemia-modified Albumin for Early Diagnosis in Patients with Contrast-induced Acute Kidney Injury

Haseki Tıp Bülteni

Alparslan Kılıç¹  Sedat Özdemir²  Aycan Fahri Erkan³  Berkay Ekici³  Ali Kemal Oğuz⁴  Ziya Apaydın⁵ 

[1] Koç University Faculty of Medicine Hospital, Clinic of Cardiology, İstanbul, Turkey;Ufuk University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey;Ufuk University Faculty of Medicine, Department of Cardiology, Ankara, Turkey;Ufuk University Faculty of Medicine, Department of Internal Diseases, Ankara, Turkey;University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Cardiology, İstanbul, Turkey;

关键词: neutrophil gelatinase-associated lipocalin;    ischemia modified albumin;    contrast-induced acute kidney injury;   

DOI  :  10.4274/haseki.galenos.2020.5847

来源: DOAJ

【 摘 要 】

Aim:The aim of this study was to investigate whether urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum ischemia-modified albumin (IMA) levels could serve as early biomarkers of contrast-induced acute kidney injury (CI-AKI) in patients with normal serum creatinine values who undergo coronary angiography (CAG).Methods:This study was conducted in 78 patients undergoing CAG. Urinary NGAL and serum IMA values which measured prior to and 6 hours after CAG were compared with creatinine values that measured prior to and 48 hours after CAG.Results:IMA and NGAL values obtained 6 hours after CAG differed significantly from those obtained at baseline. Statistically significant differences were found between the baseline and 6th-hour values of urinary NGAL and serum IMA (p<0.001). There was no significant difference between baseline and 48th hour serum creatinine levels (p=0.081). In addition, a statistically significant positive correlation was found between pre-processing and 6th-hour NGAL and IMA levels, (r=0.277, p=0.014; r=0.407 and p<0.001, respectively).Conclusion:An increase in urinary NGAL and serum IMA levels were detected without an increase in serum creatinine values which is routinely used in determining CI-AKI. When compared to serum creatinine, urinary NGAL and serum IMA may be early and sensitive biomarkers for predicting CI-AKI.

【 授权许可】

Unknown