Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions

Radiation Oncology

Christian Freudlsperger¹  Peter Plinkert²  Paul Windisch³  Stefan Rieken³  Jakob Liermann³  Klaus Herfarth³  Jürgen Debus³  Kristin Lang³  Denise Bernhardt³  Sebastian Adeberg³  Thomas Held³  Sati Akbaba³  Benjamin Farnia⁴ 

[1] Department of Oral and Maxillofacial Surgery, University Hospital Heidelberg;Department of Otorhinolaryngology, University of Heidelberg;Department of Radiation Oncology, Heidelberg University Hospital;Department of Radiation Oncology, University of Miami;

关键词: Salvage re-irradiation;    Head and neck cancer;    Carbon ions;    Mucoepidermoid carcinoma;    Particle therapy;   

DOI  :  10.1186/s13014-019-1406-x

来源: DOAJ

【 摘 要 】

Abstract Background The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment approaches in this patient cohort, which we aim to address in this work. Methods Thirty-two (n = 32) consecutive patients with uncommon HNC treated between 2010 and 2017 were retrospectively analyzed in terms of clinical outcomes, patterns of failure, and toxicity. Results Mucoepidermoid carcinoma (MEC) was the most common histology (22%). Patients received a median cumulative dose equivalent in 2 Gy fractions (EQD2) after CIR of 128.6 Gy (range, 105.8–146.5 Gy). The local and distant control rates 1 year after CIR were 66 and 72%. No serious acute or late toxicity (≥ grade 3) after CIR was observed. Conclusions CIR may represent an effective and safe treatment alternative to palliative systemic therapies in these rare indications.

【 授权许可】

Unknown