Methylobacterium extorquens RSH Enzyme Synthesizes (p)ppGpp and pppApp in vitro and in vivo, and Leads to Discovery of pppApp Synthesis in Escherichia coli

Frontiers in Microbiology

Katarzyna Potrykus¹  Michał Sobala¹  Bożena Bruhn-Olszewska¹  Michael Cashel² 

[1] Department of Bacterial Molecular Genetics, Faculty of Biology, University of Gdańsk, Gdańsk, Poland;Intramural Program, Eunice Kennedy Shriver Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States;

关键词: (p)ppGpp;    pppApp;    Rel-SpoT-homologs;    stringent response;    Methylobacterium extorquens;    Escherichia coli;   

DOI  :  10.3389/fmicb.2019.00859

来源: DOAJ

【 摘 要 】

In bacteria, the so-called stringent response is responsible for adaptation to changing environmental conditions. This response is mediated by guanosine derivatives [(p)ppGpp], synthesized by either large mono-functional RelA or bi-functional SpoT (synthesis and hydrolysis) enzymes in β- and γ-proteobacteria, such as Escherichia coli. In Firmicutes and α-, δ-, and

【 授权许可】

Unknown