Serum Lactate Level in Early Stage Is Associated With Acute Kidney Injury in Traumatic Brain Injury Patients

Frontiers in Surgery

Min He¹  Shaobo Wang²  Jianguo Xu³  Jing Zhang³  Ruoran Wang³ 

[1] Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China;Department of Infectious Diseases, Xi'an Hospital of Traditional Chinese Medicine, Xi'an, China;Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China;

关键词: serum lactate;    acute kidney injury;    traumatic brain injury;    marker;    predictive model;   

DOI  :  10.3389/fsurg.2021.761166

来源: DOAJ

【 摘 要 】

BackgroundAcute kidney injury (AKI) is a common complication in the clinical practice of managing patients with traumatic brain injury (TBI). Avoiding the development of AKI is beneficial for the prognosis of patients with TBI. We designed this study to testify whether serum lactate could be used as a predictive marker of AKI in patients with TBI.Materials and MethodsIn total, 243 patients with TBI admitted to our hospital were included in this study. Univariate and multivariate logistic regression analyses were utilized to analyze the association between lactate and AKI. The receiver operating characteristic (ROC) curves were drawn to verify the predictive value of lactate and the logistic model.ResultsAcute kidney injury group had higher age (p = 0.016), serum creatinine (p < 0.001), lactate (p < 0.001), and lower Glasgow Coma Scale (GCS; p = 0.021) than non-AKI group. Multivariate logistic regression showed that age [odds ratio (OR) = 1.026, p = 0.022], serum creatinine (OR = 1.020, p = 0.010), lactate (OR = 1.227, p = 0.031), fresh frozen plasma (FFP) transfusion (OR = 2.421, p = 0.045), and platelet transfusion (OR = 5.502, p = 0.044) were risk factors of AKI in patients with TBI. The area under the ROC curve (AUC) values of single lactate and predictive model were 0.740 and 0.807, respectively.ConclusionSerum lactate level in the early phase is associated with AKI in patients with TBI. Lactate is valuable for clinicians to evaluate the probability of AKI in patients with TBI.

【 授权许可】

Unknown