Dementia Risk Scores and Their Role in the Implementation of Risk Reduction Guidelines

Frontiers in Neurology

Neerja Chowdhary¹  Tarun Dua¹  Ruth Stephen²  Alina Solomon³  Miia Kivipelto⁴  Ruth Peters⁵  Scherazad Kootar⁵  Lidan Zheng⁵  Kaarin J. Anstey⁵  Mariagnese Barbera⁷ 

[1] Brain Health Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland;Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland;Division of Clinical Geriatrics, Department of Neurobiology, Center for Alzheimer's Research, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden;Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland;Neuroscience Research Australia, Randwick, NSW, Australia;School of Psychology, University of New South Wales, Sydney, NSW, Australia;The Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom;Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden;

关键词: dementia;    risk assessment;    risk score;    cognitive decline;    risk factors;   

DOI  :  10.3389/fneur.2021.765454

来源: DOAJ

【 摘 要 】

Dementia prevention is a global health priority. In 2019, the World Health Organisation published its first evidence-based guidelines on dementia risk reduction. We are now at the stage where we need effective tools and resources to assess dementia risk and implement these guidelines into policy and practice. In this paper we review dementia risk scores as a means to facilitate this process. Specifically, we (a) discuss the rationale for dementia risk assessment, (b) outline some conceptual and methodological issues to consider when reviewing risk scores, (c) evaluate some dementia risk scores that are currently in use, and (d) provide some comments about future directions. A dementia risk score is a weighted composite of risk factors that reflects the likelihood of an individual developing dementia. In general, dementia risks scores have a wide range of implementations and benefits including providing early identification of individuals at high risk, improving risk perception for patients and physicians, and helping health professionals recommend targeted interventions to improve lifestyle habits to decrease dementia risk. A number of risk scores for dementia have been published, and some are widely used in research and clinical trials e.g., CAIDE, ANU-ADRI, and LIBRA. However, there are some methodological concerns and limitations associated with the use of these risk scores and more research is needed to increase their effectiveness and applicability. Overall, we conclude that, while further refinement of risk scores is underway, there is adequate evidence to use these assessments to implement guidelines on dementia risk reduction.

【 授权许可】

Unknown