Neoantigen load as a prognostic and predictive marker for stage II/III non‐small cell lung cancer in Chinese patients

Thoracic Cancer

Lei Gong¹  Yanjun Xu¹  Hui Li¹  Zengguang Zheng²  Taobo Luo³  Lanxuan Liu⁴  Ronghui He⁴  Kaixiu Jin⁴  Zebin Liang⁴  Ao Li⁵  Wuzhou Yuan⁵  Zhiguo Zheng⁶ 

[1] Department of Medical Oncology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) and Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences Hangzhou China;Department of Pathology Tthe Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) and Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences Hangzhou China;Department of Thoracic Surgery The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) and Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences Hangzhou China;Hangzhou YITU Healthcare Technology Co., Ltd. Hangzhou China;Mingma Technologies Co., Ltd. Shanghai China;Zhejiang Cancer Research Institute The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) and Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences Hangzhou China;

关键词: biomarker;    neoantigen load;    NSCLC;    prognosis;    whole exome sequencing;   

DOI  :  10.1111/1759-7714.14046

来源: DOAJ

【 摘 要 】

Abstract Background The prognosis for patients with stage II/III non–small cell lung cancer (NSCLC) is unsatisfactory, even after complete tumor resection and adjuvant chemotherapy. Here, we assessed the prognostic and predictive value of immunogenomic signatures for stage II/III NSCLC in Chinese patients. Methods A total of 91 paired resected stage II/III NSCLC and normal tissues, including 47 squamous cell lung carcinomas (SCC) and 44 lung adenocarcinomas (ADC), were collected and analyzed using whole exome sequencing (WES) to identify immunogenomic signatures for association with clinicopathological variables and disease‐free survival (DFS). Results Higher neoantigen load (NAL, >2 neoantigens/Mb) exhibited better DFS for SCC patients (p = 0.021) but not ADC patients. A benefit from adjuvant chemotherapy was correlated with lower NAL (≤2 neoantigens/Mb) (p = 0.009). However, tumor mutation burden (TMB), mutations of individual gene, oncogene pathways, and antigen presentation machinery genes, and human leukocyte antigen (HLA)‐I number and HLA‐I loss of heterozygosity (LOH) had no prognostic or predictive value for DFS of SCC or ADC patients. Conclusions NAL is a useful biomarker for lung SCC prognosis and prediction of chemotherapy responses in Chinese patients. The predictive value of NAL for adjuvant immunotherapy should be further explored in patients with resected NSCLC.

【 授权许可】

Unknown