Abdominal subcutaneous adipose tissue negatively associates with subclinical coronary artery disease in men with psoriasis

American Journal of Preventive Cardiology

Amit V Khera¹  David A Bluemke²  Grigory A Manyak³  Heather L Teague³  Justin A Rodante³  Wunan Zhou³  Alexander V Sorokin³  Meron Teklu³  Promita Kapoor³  Nidhi Patel³  Nehal N Mehta³  Martin P Playford³  Amit K Dey³  Andrew Keel³  Marcus Y Chen³ 

[1] Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA;Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA;National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA;

关键词: Abdominal obesity;    Cardiovascular disease;    Inflammation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: Understand the relationship between abdominal subcutaneous adipose tissue (ASAT) and coronary atherosclerosis defined as noncalcified and lipid-rich necrotic core burden in psoriasis. Methods: We performed a cross-sectional study of 232 participants (92 women) with psoriasis and without known cardiovascular disease. Participants underwent coronary computed tomography angiography to characterize coronary atherosclerosis burden and low dose abdominal computed tomography to quantify subcutaneous and visceral adipose tissue. Fat depot volumes were first adjusted for each participant's BMI (ASATadjBMI). Results: In women, there was a positive correlation between ASATadjBMI and systemic inflammation as assessed by hs-C-reactive protein (r=0.30; p=.004) and GlycA (r=0.29; p=.007) as well as total cholesterol (r=0.24; p=.02) and low-density lipoprotein cholesterol (r=0.22; p=.04). In men, ASATadjBMI correlated with hs-C-reactive protein (r=0.18; p=.04) and insulin resistance (r=0.17; p=.04). In models fully adjusted for traditional cardiovascular risk factors, ASATadjBMI negatively associated with noncalcified and lipid-rich necrotic core burden in men (β= -0.17; p=.03, β= -0.20; p=.03, respectively), but not women (β= -0.06; p=.57, β= 0.09; p=.49, respectively) with psoriasis. Conclusions: For a given BMI, ASAT negatively associated with coronary atherosclerosis burden in male participants with psoriasis. The observed sex-specific effects warrant further study of ASAT in states of chronic inflammation.

【 授权许可】

Unknown