Guidance Level for Brevetoxins in French Shellfish

Marine Drugs

Jordi Molgó¹  Zouher Amzil²  Raphaele Le Garrec³  Vincent Hort⁴  Eric Abadie⁵  Nicolas Delcourt⁶  Nathalie Arnich⁷  Estelle Chaix⁷  Katia Comte⁸  César Mattei⁹  Marie-Yasmine Dechraoui Bottein^1,10 

[1] CEA (French Alternative Energies and Atomic Energy Commission), INRAE, University of Paris-Saclay, DMTS, SIMoS, ERL CNRS 9004, 91191 Gif sur Yvette, France;Ifremer (French Research Institute for Exploitation of the Sea), 44311 Nantes, France;Laboratoire Interactions Epitheliums Neurones (LIEN), University of Brest, 29200 Brest, France;Laboratory for Food Safety, Pesticides and Marine Biotoxins Unit, ANSES (French Agency for Food, Environmental and Occupational Health and Safety), 94701 Maisons-Alfort, France;MARBEC (MARine Biodiversity, Exploitation and Conservation), Université de Montpellier, CNRS, Ifremer, IRD, 34200 Sète, France;Poison Control Centre, Toulouse-Purpan University Hospital and Toulouse NeuroImaging Centre (ToNIC), INSERM 1214, 31059 Toulouse, France;Risk Assessment Directorate, ANSES (French Agency for Food, Environmental and Occupational Health and Safety), 94701 Maisons-Alfort, France;UMR7245 MCAM CNRS-MNHN, Muséum National d’Histoire Naturelle, 75231 Paris, France;University of Angers, INSERM, CNRS, MITOVASC, Equipe CarMe, SFR ICAT, 49100 Angers, France;Université Côte d’Azur, CNRS, ECOSEAS, UMR7035, Parc Valrose, 06108 Nice, France;

关键词: brevetoxins;    neurotoxic shellfish poisoning;    shellfish;    guidance level;    marine biotoxins;    emerging toxins;   

DOI  :  10.3390/md19090520

来源: DOAJ

【 摘 要 】

Brevetoxins (BTXs) are marine biotoxins responsible for neurotoxic shellfish poisoning (NSP) after ingestion of contaminated shellfish. NSP is characterized by neurological, gastrointestinal and/or cardiovascular symptoms. The main known producer of BTXs is the dinoflagellate Karenia brevis, but other microalgae are also suspected to synthesize BTX-like compounds. BTXs are currently not regulated in France and in Europe. In November 2018, they have been detected for the first time in France in mussels from a lagoon in the Corsica Island (Mediterranean Sea), as part of the network for monitoring the emergence of marine biotoxins in shellfish. To prevent health risks associated with the consumption of shellfish contaminated with BTXs in France, a working group was set up by the French Agency for Food, Environmental and Occupational Health & Safety (Anses). One of the aims of this working group was to propose a guidance level for the presence of BTXs in shellfish. Toxicological data were too limited to derive an acute oral reference dose (ARfD). Based on human case reports, we identified two lowest-observed-adverse-effect levels (LOAELs). A guidance level of 180 µg BTX-3 eq./kg shellfish meat is proposed, considering a protective default portion size of 400 g shellfish meat.

【 授权许可】

Unknown