Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study

Frontiers in Immunology

Hsin-Hua Chen²  James Cheng-Chung Wei⁴  Renin Chang⁶  Chiu-Yu Yeh⁸  Ting-Yu Tu⁹  Yao-Min Hung^1,13 

[1] 0Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan;1Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan;2Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan;3Division of Allergy, and Institute of Medicine, Chung Shan, Medical University, Immunology and Rheumatology, Taichung, Taiwan;College of Health and Nursing, Meiho University, Pingtung, Taiwan;Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan;Department of Medicine, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;Division of Allergy, Immunology and Rheumatology, Division of General Internal Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;Institute of Biomedical Science and Rong Hsing Research Centre for Translational Medicine, Chung Hsing University, Taichung, Taiwan;Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan;School of Medicine, National Yang Ming University, Taipei, Taiwan;

关键词: nontyphoidal Salmonella;    systemic lupus erythematosus;    NHIRD;    case-control study;    immunology;    NTS;   

DOI  :  10.3389/fimmu.2021.725996

来源: DOAJ

【 摘 要 】

ObjectiveWe investigated the correlation between nontyphoidal Salmonella (NTS) infection and systemic lupus erythematosus (SLE) risk.MethodsThis case-control study comprised 6,517 patients with newly diagnosed SLE between 2006 and 2013. Patients without SLE were randomly selected as the control group and were matched at a case-control ratio of 1:20 by age, sex, and index year. All study individuals were traced from the index date back to their NTS exposure, other relevant covariates, or to the beginning of year 2000. Conditional logistic regression analysis was used to analyze the risk of SLE with adjusted odds ratios (aORs) and 95% confidence intervals (CIs) between the NTS and control groups.ResultsThe mean age was 37.8 years in the case and control groups. Females accounted for 85.5%. The aOR of having NTS infection were significantly increased in SLE relative to controls (aOR, 9.20; 95% CI, 4.51-18.78) in 1:20 sex-age matching analysis and (aOR, 7.47; 95% CI=2.08-26.82) in propensity score matching analysis. Subgroup analysis indicated that the SLE risk was high among those who dwelled in rural areas; had rheumatoid arthritis, multiple sclerosis, or Sjogren’s syndrome; and developed intensive and severe NTS infection during admission.ConclusionsExposure to NTS infection is associated with the development of subsequent SLE in Taiwanese individuals. Severe NTS infection and other autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or Sjogren’s syndrome also contributed to the risk of developing SLE.

【 授权许可】

Unknown