High Performance of a Metal Layer-Assisted Guided-Mode Resonance Biosensor Modulated by Double-Grating

Biosensors

Yiyan Fei¹  Jiong Ma¹  Chengrui Zhang¹  Yi Zhou¹  Lan Mi¹  Xiang Wu¹ 

[1] Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), School of Information Science and Technology, Fudan University, Shanghai 200433, China;

关键词: sensors;    guided-mode resonance;    figure of merit;    grating;   

DOI  :  10.3390/bios11070221

来源: DOAJ

【 摘 要 】

Guided-mode resonance (GMR) sensors are widely used as biosensors with the advantages of simple structure, easy detection schemes, high efficiency, and narrow linewidth. However, their applications are limited by their relatively low sensitivity (<200 nm/RIU) and in turn low figure of merit (FOM, <100 1/RIU). Many efforts have been made to enhance the sensitivity or FOM, separately. To enhance the sensitivity and FOM simultaneously for more sensitive sensing, we proposed a metal layer-assisted double-grating (MADG) structure with the evanescent field extending to the sensing region enabled by the metal reflector layer underneath the double-grating. The influence of structural parameters was systematically investigated. Bulk sensitivity of 550.0 nm/RIU and FOM of 1571.4 1/RIU were obtained after numerical optimization. Compared with a single-grating structure, the surface sensitivity of the double-grating structure for protein adsorption increases by a factor of 2.4 times. The as-proposed MADG has a great potential to be a biosensor with high sensitivity and high accuracy.

【 授权许可】

Unknown