Non-invasive Tear Film Assessment in Normal Population: Effect of Age, Sex, and Interparametric Relationship

Frontiers in Medicine

Saumya Srivastav¹  Ashik Mohamed²  Swati Singh³  Sayan Basu⁴ 

[1]Centre for Ocular Regeneration, L V Prasad Eye Institute, Hyderabad, India

[2]Ophthalmic Biophysics Laboratory, L V Prasad Eye Institute, Hyderabad, India

[3]Ophthalmic Plastic Surgery Services, L V Prasad Eye Institute, Hyderabad, India

[4]The Cornea Institute, L V Prasad Eye Institute, Hyderabad, India

关键词: non-invasive tear break up time;    tear meniscus height;    tear osmolarity;    tear film parameters;    meibography;   

DOI  :  10.3389/fmed.2022.894184

来源: DOAJ

【 摘 要 】

Purpose:To investigate age- and sex-related differences in tear film parameters of normal Indian population and study interparametric relationships.MethodsHealthy subjects with no ocular disease (median ocular surface disease index = 0) were subjected to an automated evaluation of tear meniscus height (TMH), non-invasive tear breakup time (NIBUT) using Keratograph 5M (OCULUS GmbH, Wetzlar, Germany), and tear osmolarity using the TearLab Osmolarity System (TearLab Corporation, California, USA). A mixed-effects model with random intercepts at the patient level was used to evaluate the relationships between explanatory (age, gender, and tear osmolarity) and outcome variables (TMH and NIBUT).ResultsA total of 237 subjects (474 eyes; 150 males) were enrolled with a mean age of 40 ± 17 years (range, 10-78 years). The mean values (± standard deviation) of TMH, NIBUT, and tear osmolarity were 0.34 ± 0.07 mm, 10.95 ± 2.02 s and 289.0 ± 5.8 mOsm/L, respectively. Age had a significant positive relationship with TMH (p < 0.0001; 0.002 mm/year; r = 0.12), but there was no effect on NIBUT (p = 0.26) and tear osmolarity (p = 0.27). There were no sex-based differences in tear film parameters. Interparametric relationship revealed no significant association between TMH and NIBUT (p = 0.12) or tear osmolarity and TMH (p = 0.83) or tear osmolarity and NIBUT values (p = 0.48).ConclusionsIn a normal Indian population, TMH is weakly affected by age and is independent of sex, NIBUT, and tear osmolarity. Tear breakup time and osmolarity show no significant age- and sex-related variation.

【 授权许可】

Unknown