Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone

Emerging Infectious Diseases

关键词: Streptococcus pneumoniae;    fluoroquinolones;    antimicrobial drug resistance;    long-term acute care hospital;    clonal evolution;    bacteria;   

DOI  :  10.3201/eid2005.130142

来源: DOAJ

【 摘 要 】

Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006–2011 in a post–acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

【 授权许可】

Unknown