Case Report: Candida dubliniensis as a Cause of Chronic Meningitis

Frontiers in Neurology

Stephen J. Jordan¹  Andrew M. Peseski²  Madiha Tahir³ 

[1] Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States;Division of Internal Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States;The University of Vermont Health Network-Champlain Valley Physicians Hospital, Plattsburgh, NY, United States;

关键词: Candida dubliniensis;    chronic meningitis;    fungal meningitis;    case report;    intravenous drug use;    hepatitis C;   

DOI  :  10.3389/fneur.2020.601242

来源: DOAJ

【 摘 要 】

Background:Candida dubliniensis is closely related to Candida albicans and rarely isolated in clinical specimens. C. dubliniensis is increasingly recognized as a pathogen in immunocompromised hosts. We present the third known case of Candida dubliniensis meningitis in a young immunocompetent host.Case Presentation: A 27-year-old female with a history of intravenous heroin use and chronic hepatitis C presented with a 10-month history of headaches and progressive bilateral vision loss. On physical examination, visual acuity was 20/20 in her right eye and grade II papilledema was noted. Examination of her left eye revealed complete loss of vision and grade IV papilledema. An MRI with and without contrast revealed increased leptomeningeal enhancement involving the posterior fossa and spinal cord. After multiple lumbar punctures, cerebrospinal fluid fungal cultures grew Candida dubliniensis. The patient was successfully treated with a combination of liposomal amphotericin and fluconazole for 6 weeks with complete resolution of her CNS symptoms, with the exception of irreversible vision loss.Conclusion: We report a case of chronic meningitis due to Candida dubliniensis in an immunocompetent woman with hepatitis C and a history of intravenous heroin use. Additional studies are needed to confirm risk factors for Candida dubliniensis colonization, which likely predisposes individuals to invasive candidiasis.

【 授权许可】

Unknown