Injectable Hydrogel as a Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment

Frontiers in Immunology

Jing Huang¹  Yuanyuan Geng¹  Honglin Jin¹  Beilei Yue¹  Pui-Chi Lo²  Yushuai Liu³ 

[1] College of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China;Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong, SAR China;Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

关键词: cancer immunotherapy;    tumor microenvironment (TME);    injectable hydrogels;    immunogenic cell death;    abscopal effect;    controlled drug release;   

DOI  :  10.3389/fimmu.2021.832942

来源: DOAJ

【 摘 要 】

Cancer immunotherapy can boost the immune response of patients to eliminate tumor cells and suppress tumor metastasis and recurrence. However, immunotherapy resistance and the occurrence of severe immune-related adverse effects are clinical challenges that remain to be addressed. The tumor microenvironment plays a crucial role in the therapeutic efficacy of cancer immunotherapy. Injectable hydrogels have emerged as powerful drug delivery platforms offering good biocompatibility and biodegradability, minimal invasion, convenient synthesis, versatility, high drug-loading capacity, controlled drug release, and low toxicity. In this review, we summarize the application of injectable hydrogels as a unique platform for targeting the immunosuppressive tumor microenvironment.

【 授权许可】

Unknown