Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates

Revista da Sociedade Brasileira de Medicina Tropical

关键词: Klebsiella pneumoniae;    Alveolar macrophages;    Phagocytosis;    Mucoid phenotype;    Genetic characteristics;   

DOI  :  10.1590/0037-8682-0089-2019

来源: DOAJ

【 摘 要 】

AbstractINTRODUCTIONThe relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated.METHODSThirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by alveolar macrophages.RESULTSThirty percent of the samples presented the mucoid phenotype. The phagocytosis rate ranged from 21.5% to 43.43%. Phagocytosis was not correlated with the plasmid profile, but was apparently correlated with mucoid phenotype and antibiotic susceptibility.CONCLUSIONS:Several virulence factors act in parallel in K. pneumoniae to impair host defense.

【 授权许可】

Unknown