Neurophysiological mechanisms of cancer-induced bone pain

Journal of Advanced Research

Yu-hao Wu¹  Ai-Min Wu²  Xuan-Qi Zheng²  Jin-feng Huang³ 

[1] Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China;Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, Zhejiang, 325027, China;Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China;

关键词: Cancer-induced bone pain;    Central sensitization;    Neuroinflammation;    Acidic environment;    TRPV;    P2X Family;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Cancer-induced Bone Pain (CIBP) is an important factor affecting their quality of life of cancer survivors. In addition, current clinical practice and scientific research suggest that neuropathic pain is a representative component of CIBP. However, given the variability of cancer conditions and the complexity of neuropathic pain, related mechanisms have been continuously supplemented but have not been perfected. Aim of Review: Therefore, the current review highlights the latest progress in basic research on the field and proposes potential therapeutic targets, representative drugs and upcoming therapies. Key Scientific Concepts of Review: Notably, factors such as central sensitization, neuroinflammation, glial cell activation and an acidic environment are considered to be related to neuropathic pain in CIBP. Nonetheless, further research is needed to ascertain the mechanism of CIBP in order to develop highly effective drugs. Moreover, more attention needs to be paid to the care of patients with advanced cancer.

【 授权许可】

Unknown