Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain

eLife

Philip GF Browning¹  Kathy L Murphy¹  Rogier B Mars²  Paula L Croxson³  Lazar Fleysher⁴  Sean Froudist-Walsh⁵  James J Young⁵ 

[1] Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States;Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, United States;Comparative Biology Centre, Medical School, Newcastle University, United Kingdom;Department of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States;Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, United States;

关键词: non-human primates;    plasticity;    multimodal MRI;    neurotoxic lesions;    hippocampus;    network analysis;   

DOI  :  10.7554/eLife.34354

来源: DOAJ

【 摘 要 】

The brain displays a remarkable ability to adapt following injury by altering its connections through neural plasticity. Many of the biological mechanisms that underlie plasticity are known, but there is little knowledge as to when, or where in the brain plasticity will occur following injury. This knowledge could guide plasticity-promoting interventions and create a more accurate roadmap of the recovery process following injury. We causally investigated the time-course of plasticity after hippocampal lesions using multi-modal MRI in monkeys. We show that post-injury plasticity is highly dynamic, but also largely predictable on the basis of the functional connectivity of the lesioned region, gradients of cell densities across the cortex and the pre-lesion network structure of the brain. The ability to predict which brain areas will plastically adapt their functional connectivity following injury may allow us to decipher why some brain lesions lead to permanent loss of cognitive function, while others do not.

【 授权许可】

Unknown