期刊论文详细信息
Frontiers in Psychiatry
Predictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial
He Gao1  Qiang Ling1  Ya-Dong Wei1  Hua-Jun Tang1  Lu-Ying Liu2  Tao Wei2  Hua-Feng Wei2  Rui-Dong Zhou2  Wen-Juan Wang2  Yi-Ding Zhou2  Yu-Jing Wang2  Lei-Xin Chang2  Dong-Liang Jiao2  Lei Zhang2  Hua-Shan Xu2  Zi-Xuan Ren2  Li-Jin Wang2  Lin-Lin Mu2  Lin Zhu2  Wei Zhao2  Pei-Pei Song2  Yan Wang2  Xun Song2 
[1] Compulsory Isolated Drug Rehabilitation Center, Bengbu, China;School of Mental Health, Bengbu Medical College, Bengbu, China;
关键词: methamphetamine;    repetitive transcranial magnetic stimulation;    intermittent theta burst stimulation;    executive function;    craving;   
DOI  :  10.3389/fpsyt.2021.774192
来源: DOAJ
【 摘 要 】

Background: Repetitive transcranial magnetic stimulation (rTMS) has therapeutic effects on craving in methamphetamine (METH) use disorder (MUD). The chronic abuse of METH causes impairments in executive function, and improving executive function reduces relapse and improves treatment outcomes for drug use disorder. The purpose of this study was to determine whether executive function helped predict patients' responses to rTMS treatment.Methods: This study employed intermittent theta burst stimulation (iTBS) rTMS modalities and observed their therapeutic effects on executive function and craving in MUD patients. MUD patients from an isolated Drug Rehabilitation Institute in China were chosen and randomly allocated to the iTBS group and sham-stimulation group. All participants underwent the Behavior Rating Inventory of Executive Function - Adult Version Scale (BRIEF-A) and Visual Analog Scales (VAS) measurements. Sixty-five healthy adults matched to the general condition of MUD patients were also recruited as healthy controls.Findings: Patients with MUD had significantly worse executive function. iTBS groups had better treatment effects on the MUD group than the sham-stimulation group. Further Spearman rank correlation and stepwise multivariate regression analysis revealed that reduction rates of the total score of the BRIEF-A and subscale scores of the inhibition factor and working memory factor in the iTBS group positively correlated with improvements in craving. ROC curve analysis showed that working memory (AUC = 87.4%; 95% CI = 0.220, 0.631) and GEC (AUC = 0.761%; 95% CI = 0.209, 0.659) had predictive power to iTBS therapeutic efficacy. The cutoff values are 13.393 and 59.804, respectively.Conclusions: The iTBS rTMS had a better therapeutic effect on the executive function of patients with MUD, and the improved executive function had the potential to become a predictor for the efficacy of iTBS modality for MUD treatment.Clinical Trial Registration:ClinicalTrials.gov, identifier: ChiCTR2100046954.

【 授权许可】

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