期刊论文详细信息
Acta Chimica Slovenica
Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine
Rafat M. Mohareb1  Maher H. E. Helal2  Amira E. M. Abdallah2  Germeen J. Mofeed2 
[1] Department of Chemistry, Faculty of Science, Cairo University, Giza, A. R. Egypt;Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo-11795, A. R. Egypt;
关键词: anticancer;    chromene;    4-phenylthiazol-2-amine;    pyridine;    pyrimidine;    thiophene;   
DOI  :  10.17344/acsi.2020.6446
来源: DOAJ
【 摘 要 】

Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-amine. The reactivity of the latter compound toward different chemical reagents was studied. The structure of the newly synthesized compounds was established based on elemental analysis and spectral data. Furthermore, twenty compounds of the synthesized systems were selected and evaluated in (µM) as significant anticancer agents towards three human cancer cell lines [MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer)] and normal fibroblasts human cell line (WI-38). The results showed that compounds 9 and 14a displayed higher effeciency than the reference doxorubicin.

【 授权许可】

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