The pulsed ultrasound strategy effectively decreases the S. aureus population of chronic rhinosinusitis patients

BMC Research Notes

Behnoosh Vasaghi-Gharamaleki¹  Sonia Hesam-Shariati²  Jalil Kardan-Yamchi²  Mohammad Mehdi Feizabadi²  Hossein Kazemian³  Narjes Feizabadi⁴  Javad Sarrafzadeh⁴  Mahdi Dadgoo⁴  Mojtaba Fathali⁵ 

[1] Department of Basic Sciences, Faculty of Rehabilitation, Iran University of Medical Sciences;Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences;Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences;Department of Physiotherapy, Faculty of Rehabilitation, Iran University of Medical Sciences;Department of Physiotherapy, Faculty of Rehabilitation, Tehran University of Medical Sciences;

关键词: Pulsed ultrasound;    Chronic rhinosinusitis;    Staphylococcus aureus;    Treatment;    Real-time PCR;   

DOI  :  10.1186/s13104-019-4579-3

来源: DOAJ

【 摘 要 】

Abstract Objective Staphylococcus aureus with the ability of biofilm formation and the drug resistance acquisition is one of the most frequently isolated pathogens from chronic rhinosinusitis patients. Ultrasound as an alternative therapy is effectively able to kill the bacteria by cavitation in or on the bacterial cells and peroxide generation and hence improving antibiotic treatment efficacy. Results Staphylococcus aureus was detected in 4 and 6 out of 14 patients by phenotypic and qPCR assays, respectively. Four patients were completely resolved after pulsed ultrasound treatment. However, presence of the S. aureus was confirmed in three healthy controls by bacterial cultivation. Pulsed ultrasound have been quantitatively decreased the S. aureus population in chronic rhinosinusitis patients (p < 0.05). Further studies need to be investigated the effectiveness of pulsed ultrasound as an alternative course of CRS patient’s treatment.

【 授权许可】

Unknown