The effect on cognitive functions of vascular lesion localizations and vascular load in the brain

Türk Beyin Damar Hastalıkları Dergisi

İlker Öztürk¹  Yıldızhan Şengül²  Aygül Tantik Pak²  Hakan Serdar Şengül³  Sebahat Nacar Doğan⁴ 

[1] Adana City Training and Research Hospital, Depertmant of Neurology, Adana, Turkey;Gaziosmanpasa Training and Research Hospital, Depertmant of Neurology, İstanbul, Turkey;Gaziosmanpasa Training and Research Hospital, Depertmant of Psychiatry, İstanbul, Turkey;Gaziosmanpasa Training and Research Hospital, Depertmant of Radiology, İstanbul, Turkey;

关键词: white matter lesions;    dementia;    cognition;    small vessel disease;    lacunar infarct;    mini mental state examination;    vascular lesions;   

DOI  :  10.5505/tbdhd.2021.59389

来源: DOAJ

【 摘 要 】

INTRODUCTION[|]The presence of vascular lesions may be a risk factor for neurodegenerative diseases. The white matter lesions, small vessel disease, and lacunar infarcts are known to be associated with cognitive functions impairment.However, the location of these vascular lesions, and the effect of vascular load on cognition have not been clarified yet.In this study, it was aimed to investigate the effects of the localization areas of vascular lesions and vascular load on impairment of cognitive functions.[¤]METHODS[|]Fifty-two patients who underwent Mini Mental State Examination (MMSE) were included in the study. Exclusion criteria were ischemic stroke other than small vessel disease, alcohol abuse, and traumatic brain disease. The MMSE were divided into subitems (orientation, recording memory, attention and calculation, recall, and language). The magnetic resonance imagings (MRI) of the patients were analyzed. The locations areas of the vascular lesions (juxtacortical, periventricular and deep brain structures), and the presence of subcortical atrophy were recorded. Fazekas scale was used for the severity of vascular lesion load.[¤]RESULTS[|]The mean age of the patients was 75.01+-10.23 (range 53-84) years; 61.5% of the patients were female. MMSE was normal in 14 (26.9%) of the patients. The factors affecting the orientation in the multiple regression analysis were as follows: subcortical atrophy (p= 0.036, β= -0.323), and periventricular vascular lesions (p= 0.024, β= -0.449). The recall was found to be affected by subcortical atrophy (p= 0.048, β= -0.295). Additionally, it was analyzed that subcortical atrophy (p= 0.024, β= -0.345), juxtacortical area (p= 0.028, β= -0.423), and vascular lesions located in deep brain structures (p= 0.031, β= -0.395) affected the recording memory. The only factor affecting the MMSE was the subcortical atrophy (p= 0.034, β= -0.341). Subcortical atrophy was found to be the only effective factor in detecting dementia (p= 0.034, β= 0.291).[¤]DISCUSSION AND CONCLUSION[|]It was found that subcortical atrophy detected in MRI was the most effective factor in the development and progression of dementia, and that vascular load had no effect on dementia.[¤]

【 授权许可】

Unknown