Characteristics of the corpus callosum in chronic schizophrenia treated with clozapine or risperidone and those never-treated

BMC Psychiatry

Hengyi Cao¹  Rebekka Lencer²  Su Lui³  Bo Tao³  Qiyong Gong³  Yuan Xiao³  Wenjing Zhang³  Chengmin Yang³ 

[1] Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research;Department of Psychiatry and Psychotherapy, University of Lübeck;Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University;

关键词: corpus callosum (CC);    Magnetic resonance imaging (MRI);    Diffusion tensor imaging (DTI);    Fractional anisotropy (FA);    Clozapine;    Risperidone;   

DOI  :  10.1186/s12888-021-03552-0

来源: DOAJ

【 摘 要 】

Abstract Background The corpus callosum (CC) deficits have been well documented in chronic schizophrenia. However, the long-term impacts of antipsychotic monotherapies on callosal anatomy remain unclear. This cross-sectional study sought to explore micro- and macro-structural characteristics of the CC in never-treated patients and those with long-term mono-antipsychotic treatment. Methods The study included 23 clozapine-treated schizophrenia patients (CT-SCZ), 19 risperidone-treated schizophrenia patients (RT-SCZ), 23 never-treated schizophrenia patients (NT-SCZ), and 35 healthy controls (HCs). High resolution structural images and diffusion tensor imaging (DTI) data for each participant were obtained via a 3.0 T MR scanner. FreeSurfer was used to examine the volumes and fractional anisotropy (FA) values of the CC for each participant. Results There were significant deficits in the total and sub-regional CC volume and white matter integrity in NT-SCZ in comparison with healthy subjects. Compared with NT-SCZ, both CT-SCZ and RT-SCZ showed significantly increased FA values in the anterior CC region, while only RT-SCZ showed significantly increased volume in the mid-anterior CC region. Moreover, the volume of the mid-anterior CC region was significantly smaller in CT-SCZ compared to HCs. No correlations of clinical symptoms with callosal metrics were observed in schizophrenia patients. Conclusions Our findings provide insight into micro- and macro-structural characteristics of the CC in chronic schizophrenia patients with or without antipsychotics. These results suggest that the pathology itself is responsible for cerebral abnormalities in schizophrenia and that chronic exposure to antipsychotics may have an impact on white matter structure of schizophrenia patients, especially in those with risperidone treatment.

【 授权许可】

Unknown