Association Between Lipoprotein(a) and Calcific Aortic Valve Disease: A Systematic Review and Meta-Analysis

Frontiers in Cardiovascular Medicine

Jingen Li¹  Yanqiao Yu²  Qiyu Liu²  Zihao Zhang²  Tongxin Wang²  Yixuan Fan²  Hao Xu³  Ruixi Xi³  Jianqing Ju³  Runmin Lai³ 

[1] Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China;Graduate School, Beijing University of Chinese Medicine, Beijing, China;National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China;

关键词: lipoprotein(a);    calcific aortic valve disease;    aortic valve stenosis;    aortic valve calcification;    systematic review and meta-analysis;   

DOI  :  10.3389/fcvm.2022.877140

来源: DOAJ

【 摘 要 】

BackgroundPreliminary studies indicated that enhanced plasma levels of lipoprotein(a) [lp(a)] might link with the risk of calcific aortic valve disease (CAVD), but the clinical association between them remained inconclusive. This systematic review and meta-analysis were aimed to determine this association.MethodsWe comprehensively searched PubMed, Embase, Web of Science, and Scopus databases for studies reporting the incidence of CAVD and their plasma lp(a) concentrations. Pooled risk ratio (RR) and 95% confidence interval (95% CI) were calculated to evaluate the effect of lp(a) on CAVD using the random-effects model. Subgroup analyses by study types, countries, and the level of adjustment were also conducted. Funnel plots, Egger's test and Begg's test were conducted to evaluate the publication bias.ResultsEight eligible studies with 52,931 participants were included in this systematic review and meta-analysis. Of these, four were cohort studies and four were case-control studies. Five studies were rated as high quality, three as moderate quality. The pooled results showed that plasma lp(a) levels ≥50 mg/dL were associated with a 1.76-fold increased risk of CAVD (RR, 1.76; 95% CI, 1.47–2.11), but lp(a) levels ≥30 mg/dL were not observed to be significantly related with CAVD (RR, 1.28; 95% CI, 0.98–1.68). We performed subgroup analyses by study type, the RRs of cohort studies revealed lp(a) levels ≥50 mg/dL and lp(a) levels ≥30 mg/dL have positive association with CAVD (RR, 1.70; 95% CI, 1.39–2.07; RR 1.38; 95% CI, 1.19–1.61).ConclusionHigh plasma lp(a) levels (≥50 mg/dL) are significantly associated with increased risk of CAVD.

【 授权许可】

Unknown