Impact of Environmental Conditions on Growth and the Phenolic Profile of Achillea atrata L.

Processes

Otmar Spring¹  Peter Lorenz²  FlorianC. Stintzing²  Lysanne Salomon²  DietmarR. Kammerer²  Bernhard Ehrmann³ 

[1] Institute of Botany, Hohenheim University, 70599 Stuttgart, Germany;WALA Heilmittel GmbH, Department of Analytical Development & Research, Section Phytochemical Research, 73087 Bad Boll, Germany;WALA Heilmittel GmbH, Department of Manufacturing, WALA Medicinal Herb Garden, 73087 Bad Boll, Germany;

关键词: black yarrow;    chemotype;    cultivation;    phenolic profiling;   

DOI  :  10.3390/pr9050853

来源: DOAJ

【 摘 要 】

Achillea atrata L. is a traditionally used medicinal plant. With its pronounced antimicrobial potential, this alpine Achillea species may also be used in modern phytotherapy to treat MRSA infections and prevent dermal infections, such as acne vulgaris. For the present study, A. atrata was cultivated in its natural habitat in Switzerland as well as in Germany to elucidate the potential of standardizing plant material derived from this species for pharmaceutical production. Phytochemical characterization of phenolic constituents by HPLC-DAD-MSⁿ revealed that environmental conditions have only a minor impact on the phenolic profile. Metabolic differences between cultivated and wild plants grown in the same environment suggested the possible existence of genetically derived chemotypes. In total, 28 substances were identified, with marked differences in the occurrence of phenolic compounds observed between flowers and leaves. Moreover, to the best of our knowledge, 7 phenolic compounds have been reported for the first time in A. atrata in the present study. The quantitation of individual constituents revealed their contents to depend on environmental factors and to reach their maximum at increasing altitudes. The results here presented may help to select and cultivate A. atrata plant material with defined and constant compound profiles, which is of particular importance for potential pharmaceutical use.

【 授权许可】

Unknown