Complement as a Therapeutic Target in Systemic Autoimmune Diseases

Cells

María Galindo-Izquierdo¹  JoséLuis Pablos Alvarez¹ 

[1] Servicio de Reumatología, Instituto de Investigación 12 de Octubre, Universidad Complutense de Madrid, 28040 Madrid, Spain;

关键词: complement system;    pathogenesis;    therapeutic blockade;    rheumatic autoimmune diseases;   

DOI  :  10.3390/cells10010148

来源: DOAJ

【 摘 要 】

The complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune responses. Pathological activation plays prominent roles in the pathogenesis of most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, and ANCA-associated vasculitis. In this review, we will review the main rheumatologic autoimmune processes in which complement plays a pathogenic role and its potential relevance as a therapeutic target.

【 授权许可】

Unknown