In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts

Environment International

Maribel Casas¹  Maria-Jose Lopez-Espinosa²  Tiffany C. Yang³  Marina Vafeiadi⁴  Talita Duarte-Salles⁵  Leonardo Trasande⁶  Raquel Garcia-Esteban⁷  Liesbeth Duijts⁸  Berit Granum⁹  Andrea Beneito⁹  Susana Santos⁹  Amrit K. Sakhi^1,10  Judith Garcia-Aymerich^1,10  Sara M. Mensink-Bout^1,10  Vincent W.V. Jaddoe^1,11  Carlos Zabaleta^1,12  Carmen Iñiguez^1,13  Kurunthachalam Kannan^1,14  Alicia Abellan^1,15  Mariana F. Fernandez^1,15  Claire Philippat^1,15  Valérie Siroux^1,16  Martine Vrijheid^1,17  Aitana Lertxundi^1,17  Jordi Sunyer^1,17  Fernando Vela-Soria^1,18  Leda Chatzi^1,18 

[1] Biodonostia Health research institute, Donostia-San Sebastian, Spain;Centro de Investigación Biomédica, University of Granada, Granada, Spain;Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands;Department of Statistics and Operational Research. Universitat de València. València, Spain;Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands;Epidemiology and Environmental Health Joint Research Unit, FISABIO–Universitat Jaume I–Universitat de València, Valencia, Spain;Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain;Preventive medicine and public health department, University of Basque Country (UPV/EHU), Leioa, Spain;Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain;Universitat Pompeu Fabra (UPF), Barcelona, Spain;Department of Preventive Medicine, University of Southern California, Los Angeles, USA;Departments of Pediatrics and Environmental Medicine, New York University School of Medicine, New York, NY, United States;Epidemiology and Environmental Health Joint Research Unit, FISABIO–Universitat Jaume I–Universitat de València, Valencia, Spain;Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain;ISGlobal, Barcelona, Spain;Norwegian Institute of Public Health, Oslo, Norway;Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain;The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands;

关键词: Bisphenol A;    Pregnancy;    Asthma;    Wheezing;    Lung function;    Mother-child cohort;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: In utero exposure to bisphenols, widely used in consumer products, may alter lung development and increase the risk of respiratory morbidity in the offspring. However, evidence is scarce and mostly focused on bisphenol A (BPA) only. Objective: To examine the associations of in utero exposure to BPA, bisphenol F (BPF), and bisphenol S (BPS) with asthma, wheeze, and lung function in school-age children, and whether these associations differ by sex. Methods: We included 3,007 mother–child pairs from eight European birth cohorts. Bisphenol concentrations were determined in maternal urine samples collected during pregnancy (1999–2010). Between 7 and 11 years of age, current asthma and wheeze were assessed from questionnaires and lung function by spirometry. Wheezing patterns were constructed from questionnaires from early to mid-childhood. We performed adjusted random-effects meta-analysis on individual participant data. Results: Exposure to BPA was prevalent with 90% of maternal samples containing concentrations above detection limits. BPF and BPS were found in 27% and 49% of samples. In utero exposure to BPA was associated with higher odds of current asthma (OR = 1.13, 95% CI = 1.01, 1.27) and wheeze (OR = 1.14, 95% CI = 1.01, 1.30) (p-interaction sex = 0.01) among girls, but not with wheezing patterns nor lung function neither in overall nor among boys. We observed inconsistent associations of BPF and BPS with the respiratory outcomes assessed in overall and sex-stratified analyses. Conclusion: This study suggests that in utero BPA exposure may be associated with higher odds of asthma and wheeze among school-age girls.

【 授权许可】

Unknown