Interoceptive Abilities in Inflammatory Bowel Diseases and Irritable Bowel Syndrome

Frontiers in Psychiatry

Cécile Dantzer¹  Bruno Bonaz²  Sonia Pellissier³  Olivier Luminet⁴  Anne Sophie Gauchez⁵  Alicia Fournier⁶  Nicolas Mathieu⁸  Laurie Mondillon^1,10  Fréderic Canini^1,12 

[1] 0Université de Bordeaux, Laboratoire de Psychologie, Bordeaux, France;1Université Grenoble Alpes, Grenoble Institute of Neurosciences, Grenoble, France;2Université Savoie Mont Blanc, LIP/PC2S, Chambéry, France;Fund for Scientific Research (FRS-FNRS), Brussels, Belgium;Institut de Biologie et Pathologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France;MSHE Claude-Nicolas Ledoux, USR3124, Behaviors, Risk and Health, Besançon, France;Research Institute for Psychological Sciences, Université catholique de Louvain, Louvain-La-Neuve, Belgium;Service d’Hépato-Gastroentérology, Centre Hospitalier Universitaire de Grenoble, Grenoble, France;Unité de Neurophysiologie du Stress, Institut de Recherche Biomédicale des Armées (IRBA), Brétigny sur Orge, France;Université Clermont Auvergne, CNRS, Laboratoire de Psychologie Sociale et Cognitive, Team on Physiological and Psychosocial Stress, Well-being Physiological and Psychosocial Stress, Clermont-Ferrand, France;Université de Bourgogne, Laboratoire Psy-DREPI, Dijon, France;École du Val de Grâce, Paris, France;

关键词: inflammatory bowel disease;    irritable bowel syndrome;    alexithymia;    interoceptive abilities;    hypothalamic-pituitary adrenal axis;   

DOI  :  10.3389/fpsyt.2020.00229

来源: DOAJ

【 摘 要 】

Alexithymia is usually described by three main dimensions difficulty identifying feelings (DIF), difficulty describing feelings (DDF), and externally oriented thinking (EOT). The most commonly used questionnaire investigating alexithymia, the Toronto Alexithymia Scale (TAS-20), supports this three-factor structure. One important assumption is that alexithymia severity is associated to vulnerability to somatic diseases, among them gastrointestinal disorders. However, the association between alexithymia and gastrointestinal disorders is not systematic, thus questioning the role of alexithymia as a vulnerability factor for those illnesses. A recent factor analysis suggested another four-factor structure for the TAS-20: difficulties in awareness of feelings (DAF), difficulties in interoceptive abilities (DIA), externally oriented thinking (EOT), and poor affective sharing (PAS). We assume that DIA and DAF might be more relevant to investigate the association between alexithymia and gastrointestinal disorders. The rationale is that DIA and DAF reflect impairments in emotion regulation that could contribute to an inappropriate autonomic and HPA axis homeostasis in irritable bowel syndrome (IBS), ulcerative colitis (UC), or Crohn’s disease (CD). The aim of this study was to investigate whether DIA and DAF are associated with the presence of IBS, UC or CD, while checking for anxiety, depression, parasympathetic (vagus nerve) activity and cortisol levels. We recruited control participants (n=26), and patients in remission who were diagnosed with IBS (n=24), UC (n=18), or CD (n=21). Participants completed questionnaires to assess anxiety, depression, and alexithymia. A blood sample and an electrocardiogram were used to measure the level of cortisol and parasympathetic activity, respectively. Logistic regressions with the four-factor structure of the TAS-20 revealed that DIA was a significant predictor of IBS (W(1)=6.27, p=.01). Conversely, DIA and DAF were not significant predictors in CD and UC patients. However, low cortisol level was a significant predictor of UC (W(1)=4.67, p=.035). Additional logistic regressions based on the original 3-factor structure of TAS-20 (DIF, DDF, and EOT) showed that only DDF was a significant predictor of CD [W(1)=6.16, p < .001]. The present study suggests that DIA is an important dimension for assessing potential risk for gastrointestinal diseases, in particular for IBS.

【 授权许可】

Unknown