PD-L1 immune suppression in cancer: Tumor cells or host cells?

OncoImmunology

Jan Willem Kleinovink¹  Marieke F. Fransen¹  Ferry Ossendorp¹  Thorbald van Hall¹ 

[1] Leiden University Medical Center;

关键词: biomarker;    checkpoint blockade;    expression;    immunotherapy;    pd-1;    pd-l1;   

DOI  :  10.1080/2162402X.2017.1325982

来源: DOAJ

【 摘 要 】

Four recent publications reported the role of PD-L1 expression on host versus malignant cells within the tumor for PD-1/PD-L1 checkpoint blockade therapy. All four research groups harmoniously report: PD-L1 expressed by both host as well as tumor cells are capable of suppressing T cell functions. Thus, checkpoint therapy can be effective, if malignant cells do not express PD-L1.

【 授权许可】

Unknown