Treatment effects of Shilajit on aspirin‐induced gastric lesions in rats

Physiological Reports

Naghmeh Ghasemkhani¹  Aidin Shojaee Tabrizi¹  Saeed Nazifi¹  Fatemeh Namazi² 

[1] Department of Clinical Studies School of Veterinary Medicine Shiraz University Shiraz Iran;Department of Pathobiology School of Veterinary Medicine Shiraz University Shiraz Iran;

关键词: antioxidant;    aspirin;    gastric lesion;    shilajit;   

DOI  :  10.14814/phy2.14822

来源: DOAJ

【 摘 要 】

Abstract The present study investigated the effects of Shilajit extract on aspirin‐induced gastric lesions in rats. We evaluated macroscopic and histopathological lesions in the stomach, measured the activity of oxidative stress enzymes in gastric tissue homogenates, and assessed serum electrolytes and parameters of kidney and liver function. Forty‐five male rats were allocated to five groups: Normal control, positive control, omeprazole treatment, Shilajit treatment, and Shilajit control. The treatment period lasted for four consecutive days. The size and number of gastric lesions were significantly reduced in the Shilajit and omeprazole groups compared to the positive control group, indicating a reduction in mucosal damage and the severity of edema and leukocyte infiltration in tissue sections. A significant increase was observed in the levels of all oxidative stress parameters, except malondialdehyde, in rats treated with Shilajit and omeprazole compared to those in the positive control group. The effect of the aqueous extract of Shilajit was comparable to that of omeprazole. These results indicated the protective effects of Shilajit against aspirin‐induced gastric lesions.

【 授权许可】

Unknown