Progress towards a cellular neurobiology of reading disability

Neurobiology of Disease

Jeffrey R. Gruen¹  Joseph J. LoTurco²  Christopher J. Gibson²  Lisa A. Gabel³ 

[1] Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT, USA;Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT, USA;Department of Psychology and Program in Neuroscience, Lafayette College, Easton, PA, USA;

关键词: Dyslexia;    Neocortex;    Neuronal migration;    Development;    DCDC2;    KIAA0319;   

DOI  :  

来源: DOAJ

【 摘 要 】

Reading Disability (RD) is a significant impairment in reading accuracy, speed and/or comprehension despite adequate intelligence and educational opportunity. RD affects 5–12% of readers, has a well-established genetic risk, and is of unknown neurobiological cause or causes. In this review we discuss recent findings that revealed neuroanatomic anomalies in RD, studies that identified 3 candidate genes (KIAA0319, DYX1C1, and DCDC2), and compelling evidence that potentially link the function of candidate genes to the neuroanatomic anomalies. A hypothesis has emerged in which impaired neuronal migration is a cellular neurobiological antecedent to RD. We critically evaluate the evidence for this hypothesis, highlight missing evidence, and outline future research efforts that will be required to develop a more complete cellular neurobiology of RD.

【 授权许可】

Unknown