Crizotinib resistance: BRAF mutation implications for therapeutic strategies

Cancer Treatment and Research Communications

Li Xie¹ 

[1] Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;

关键词: Crizotinib;    Resistance;    Braf mutation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Drug-resistant mutations constitute a significant cause of crizotinib treatment failure for non-small cell lung cancer, which poses a major clinical challenge in the successful treatment of non-small cell lung cancer; therefore, the discovery of the resistance mechanisms of crizotinib is of utmost importance. Understanding the acquired BRAF 600E mutation is essential for designing new effective therapeutic combinations against disease progression.

【 授权许可】

Unknown