Retinal Blood Velocity and Flow in Early Diabetes and Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy

Journal of Clinical Medicine

RobertA. Linsenmeier¹  AmaniA. Fawzi²  HeeEun Lee²  Andrew Geng²  CherilynMae A. Palochak²  Jessica Song²  StephenA. Burns³ 

[1] Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA;Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;School of Optometry, Indiana University, Bloomington, IN 47405, USA;

关键词: adaptive optics scanning laser ophthalmoscopy;    optical coherence tomography angiography;    diabetic retinopathy;    diabetes mellitus;    retina;    blood flow;   

DOI  :  10.3390/jcm8081165

来源: DOAJ

【 摘 要 】

Using adaptive optics scanning laser ophthalmoscopy (AOSLO), we measured retinal blood velocity and flow in healthy control eyes and eyes of diabetic patients with or without retinopathy. This cross-sectional study included 39 eyes of 30 patients with diabetes (DM) with mild non-proliferative diabetic retinopathy (NPDR) or without retinopathy (DM no DR) and 21 eyes of 17 healthy age-matched controls. Participants were imaged with a commercial optical coherence tomography angiography (OCTA) device (RTVue-XR Avanti) and AOSLO device (Apaeros Retinal Imaging System, Boston Micromachines). We analyzed AOSLO-based retinal blood velocity and flow, and OCTA-based vessel density of the superficial (SCP), deep retinal capillary plexus (DCP), and full retina. Retinal blood velocity was significantly higher in eyes with DM no DR and lower in NPDR across all vessel diameters compared to controls. Retinal blood flow was significantly higher in DM no DR and lower in NPDR in vessel diameters up to 60 μm compared to controls. When comparing flow outliers (low-flow DM no DR eyes and high-flow NPDR eyes), we found they had a significantly different retinal vessel density compared to the remaining eyes in the respective groups. Retinal blood velocity and flow is increased in eyes with DM no DR, while these parameters are decreased in eyes with mild NPDR compared to healthy age-matched controls. The similarity of OCTA vessel density among outliers in the two diabetic groups suggests an initial increase followed by progressive decline in blood flow and OCTA vessel density with progression to clinical retinopathy, which warrants further investigation.

【 授权许可】

Unknown