Neural Stem Cells and Ischemic Brain

Journal of Stroke

Zhenggang Zhang¹  Michael Chopp¹ 

[1] Henry Ford Hospital, Michigan, United States;

关键词: adult neurogenesis;    stroke;    brain repair;    stem cells;   

DOI  :  10.5853/jos.2016.00206

来源: DOAJ

【 摘 要 】

Stroke activates neural stem cells in the ventricular-subventricular zone (V/SVZ) of the lateral ventricle, which increases neuroblasts and oligodendrocyte progenitor cells (OPCs). Within the ischemic brain, neural stem cells, neuroblasts and OPCs appear to actively communicate with cerebral endothelial cells and other brain parenchymal cells to mediate ischemic brain repair; however, stroke-induced neurogenesis unlikely plays any significant roles in neuronal replacement. In this mini-review, we will discuss recent findings how intercellular communications between stroke-induced neurogenesis and oligodendrogenesis and brain parenchymal cells could potentially facilitate brain repair processes.

【 授权许可】

Unknown