SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES

Indonesian Journal of Chemistry

Shishupal Singh¹  Nidhi Chaudhary²  Hemant Panwar³ 

[1] Department of Chemistry, Aligarh Muslim University, Aligarh-202002, U.P.;Department of Chemistry, I.I.M.T., I.E.T., Ganga Nagar, Meerut-250001, U.P.;Depatment of Chemistry, Neelkanth Institute of Technology, Modipuram-250110, Meerut, U.P.;

关键词: Indoles;    Antifungal;    Antibacterial;    Acute toxicity;   

DOI  :  10.22146/ijc.21380

来源: DOAJ

【 摘 要 】

In the present study, a series of 2-(4´-Substitutedanilinosydnon-3´-yl)-1, 3, 4-thiadiazino (6, 5-b) indoles 7a-j have been synthesized. All the synthesized compounds have been characterized by elemental and spectral (I R, 1H- NMR and Mass) spectrometric analysis. Furthermore, above mentioned compounds were evaluated for their antibacterial and antifungal activities against selected panel of pathogenic strains. Ampicillin trihydrate, ofloxacin and fluconazole, griseofulvin were used as standard drugs for antibacterial and anifungal activity respectively. Compound 7j was found the most potent one with lesser toxicity in the prepared indole derivatives.

【 授权许可】

Unknown