Effects of pomegranate peel extract and vitamin E on oxidative stress and antioxidative capacity of hemodialysis patients: A randomized controlled clinical trial

Journal of Functional Foods

Zahra Lorigooini¹  Aziz A. Fallah¹  Tina Jafari²  Mohsen Bahrami³ 

[1] Corresponding authors.;Department of Biochemistry and Nutrition, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran;Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord 34141, Iran;

关键词: Pomegranate peel extract;    Vitamin E;    Oxidative stress;    Antioxidant;    Hemodialysis;    Clinical trial;   

DOI  :  

来源: DOAJ

【 摘 要 】

This study aimed to assess the effects of 8-week administration of pomegranate peel extract (PPE, ~180 mg ellagic acid) and vitamin E (Vit E, 400 IU) alone and in combination on oxidative stress (OS) and antioxidative capacity of hemodialysis (HD) patients. One hundred HD patients randomly divided in to 4 groups (control, PPE, Vit E, and PPE + Vit E). The changes of malondialdehyde, oxidized low-density lipoprotein, and myeloperoxidase in PPE + Vit E, PPE, and Vit E groups were significantly different compared to placebo group. The Changes of advanced oxidation protein products, superoxide dismutase, and oxygen radical absorbance capacity in PPE + Vit E group and changes of protein carbonyls in PPE and PPE + Vit E groups were significantly different compared to the other groups. As a result, consumption of PPE combined with Vit E was more effective than PPE or Vit E alone to ameliorate OS and enhance antioxidative capacity of HD patients.

【 授权许可】

Unknown